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2VQV

Structure of HDAC4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor

Summary for 2VQV
Entry DOI10.2210/pdb2vqv/pdb
Related2VQJ 2VQM 2VQO 2VQQ 2VQW
DescriptorHISTONE DEACETYLASE 4, SULFATE ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywordsinhibitor, repressor, chromatin, coiled coil, histone deacetylase, transcription regulation, ubl conjugation, chromatin regulator, polymorphism, transcription, phosphoprotein, hdac, zinc, hdaci, nucleus, hydrolase, cytoplasm
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus: P56524
Total number of polymer chains2
Total formula weight90284.88
Authors
Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. (deposition date: 2008-03-19, release date: 2008-07-22, Last modification date: 2023-12-13)
Primary citationBottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A.
Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
J.Biol.Chem., 283:26694-, 2008
Cited by
PubMed: 18614528
DOI: 10.1074/JBC.M803514200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3 Å)
Structure validation

217705

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