2VIF
Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide
Summary for 2VIF
Entry DOI | 10.2210/pdb2vif/pdb |
Related | 1PKG 1QZJ 1QZK 1R01 1T45 1T46 |
Descriptor | SUPPRESSOR OF CYTOKINE SIGNALLING 6, MAST/STEM CELL GROWTH FACTOR RECEPTOR, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | growth regulation, signal transduction inhibitor, kit regulator, phosphotyrosine, signaling protein |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Membrane; Single-pass type I membrane protein: P10721 |
Total number of polymer chains | 2 |
Total formula weight | 17330.08 |
Authors | Bullock, A.,Pike, A.C.W.,Savitsky, P.,Keates, T.,Pilka, E.S.,von Delft, F.,Edwards, A.,Weigelt, J.,Arrowsmith, C.H.,Knapp, S. (deposition date: 2007-11-30, release date: 2007-12-25, Last modification date: 2023-12-13) |
Primary citation | Zadjali, F.,Pike, A.C.W.,Vesterlund, M.,Sun, J.,Wu, C.,Li, S.S.,Ronnstrand, L.,Knapp, S.,Bullock, A.,Flores-Morales, A. Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase. J.Biol.Chem., 286:480-, 2011 Cited by PubMed: 21030588DOI: 10.1074/JBC.M110.173526 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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