2VHS

Cathsilicatein, a chimera

2VHS の概要

• エントリーDOI: 10.2210/pdb2vhs/pdb
• 分子名称: CATHSILICATEIN, SULFATE ION (3 entities in total)
• 機能のキーワード: zymogen, protease, lysosome, hydrolase, glycoprotein, thiol protease, silica condensation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Lysosome: P07711
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95645.98

構造登録者

Fairhead, M.,Kowatz, T.,McMahon, S.A.,Carter, L.G.,Oke, M.,Johnson, K.A.,Liu, H.,Naismith, J.H.,Wal, C.F.V.D. (登録日: 2007-11-24, 公開日: 2008-03-11, 最終更新日: 2024-11-13)

主引用文献

Fairhead, M.,Johnson, K.A.,Kowatz, T.,Mcmahon, S.A.,Carter, L.G.,Oke, M.,Liu, H.,Naismith, J.H.,Van Der Walle, C.F.
Crystal Structure and Silica Condensing Activities of Silicatein Alpha-Cathepsin L Chimeras.
Chem. Commun., :1765-, 2008

PubMed Abstract: Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 A crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

PubMed: 18379686
DOI: 10.1039/B718264C

実験手法

X-RAY DIFFRACTION (1.5 Å)