2VFI

Crystal structure of the Plasmodium falciparum triosephosphate isomerase in the loop closed state with 3-phosphoglycerate bound at the active site and interface

Summary for 2VFI

• Entry DOI: 10.2210/pdb2vfi/pdb
• Related: 1LYX 1LZO 1M7O 1M7P 1O5X 1VGA 1WOA 1WOB 1YDV 2VFD 2VFE 2VFF 2VFG 2VFH
• Descriptor: TRIOSEPHOSPHATE ISOMERASE, 3-PHOSPHOGLYCERIC ACID (3 entities in total)
• Functional Keywords: plasmodium falciparum, fatty acid biosynthesis, triosephosphate isomerase, tim, mutant, isomerase, glycolysis, loop closed, pentose shunt, gluconeogenesis, lipid synthesis
• Biological source: PLASMODIUM FALCIPARUM (MALARIAL PARASITE)
• Total number of polymer chains: 2
• Total formula weight: 56739.70

Authors

Gayathri, P.,Banerjee, M.,Vijayalakshmi, A.,Balaram, H.,Balaram, P.,Murthy, M.R.N. (deposition date: 2007-11-04, release date: 2008-12-09, Last modification date: 2023-12-13)

• Primary citation: Gayathri, P.,Banerjee, M.,Vijayalakshmi, A.,Balaram, H.,Balaram, P.,Murthy, M.R.N.; Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site.; Acta Crystallogr.,Sect.D, 65:847-, 2009; PubMed: 19622869; DOI: 10.1107/S0907444909018666

Experimental method

X-RAY DIFFRACTION (2.25 Å)