2VD7
Crystal Structure of JMJD2A complexed with inhibitor Pyridine-2,4- dicarboxylic acid
Summary for 2VD7
Entry DOI | 10.2210/pdb2vd7/pdb |
Related | 2GF7 2GFA 2GP3 2GP5 |
Descriptor | JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3A, NICKEL (II) ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | oxidoreductase, phosphorylation, chromatin regulator, iron, nucleus, zinc-finger, dioxygenase, host-virus interaction, transcription regulation, transcription, metal-binding, histone demethylation inhibitor jmjc domain |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : O75164 |
Total number of polymer chains | 2 |
Total formula weight | 89234.99 |
Authors | Ng, S.S.,von Delft, F.,Pilka, E.S.,Kavanagh, K.L.,McDonough, M.A.,Savitsky, P.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Sundstrom, M.,Schofield, C.J.,Oppermann, U. (deposition date: 2007-10-01, release date: 2007-11-27, Last modification date: 2024-05-08) |
Primary citation | Rose, N.R.,Ng, S.S.,Mecinovic, J.,Lienard, B.M.,Bello, S.H.,Sun, Z.,McDonough, M.A.,Oppermann, U.,Schofield, C.J. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J. Med. Chem., 51:7053-7056, 2008 Cited by PubMed: 18942826DOI: 10.1021/jm800936s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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