2VD7

Crystal Structure of JMJD2A complexed with inhibitor Pyridine-2,4- dicarboxylic acid

2VD7 の概要

• エントリーDOI: 10.2210/pdb2vd7/pdb
• 関連するPDBエントリー: 2GF7 2GFA 2GP3 2GP5
• 分子名称: JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3A, NICKEL (II) ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, phosphorylation, chromatin regulator, iron, nucleus, zinc-finger, dioxygenase, host-virus interaction, transcription regulation, transcription, metal-binding, histone demethylation inhibitor jmjc domain
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : O75164
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89234.99

構造登録者

Ng, S.S.,von Delft, F.,Pilka, E.S.,Kavanagh, K.L.,McDonough, M.A.,Savitsky, P.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Sundstrom, M.,Schofield, C.J.,Oppermann, U. (登録日: 2007-10-01, 公開日: 2007-11-27, 最終更新日: 2024-05-08)

主引用文献

Rose, N.R.,Ng, S.S.,Mecinovic, J.,Lienard, B.M.,Bello, S.H.,Sun, Z.,McDonough, M.A.,Oppermann, U.,Schofield, C.J.
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
J. Med. Chem., 51:7053-7056, 2008

PubMed Abstract: The dynamic methylation of histone lysyl residues plays an important role in biology by regulating transcription, maintaining genomic integrity, and by contributing to epigenetic effects. Here we describe a variety of inhibitor scaffolds that inhibit the human 2-oxoglutarate-dependent JMJD2 subfamily of histone demethylases. Combined with structural data, these chemical starting points will be useful to generate small-molecule probes to analyze the physiological roles of these enzymes in epigenetic signaling.

PubMed: 18942826
DOI: 10.1021/jm800936s

実験手法

X-RAY DIFFRACTION (2.25 Å)