2VD5

Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII

Summary for 2VD5

• Entry DOI: 10.2210/pdb2vd5/pdb
• Descriptor: DMPK PROTEIN, 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE (3 entities in total)
• Functional Keywords: serine/threonine-protein kinase, kinase, transferase, atp-binding, nucleotide-binding, cardiac contractility, muscle differentiation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 93007.64

Authors

Pike, A.C.W.,Amos, A.,Elkins, J.,Bullock, A.,Guo, K.,Fedorov, O.,Bunkoczi, G.,Filippakopoulos, P.,Pilka, E.S.,Ugochukwu, E.,Umeano, C.,Niesen, F.,Sundstrom, M.,Weigelt, J.,Edwards, A.,Arrowsmith, C.H.,von Delft, F.,Knapp, S. (deposition date: 2007-09-30, release date: 2007-11-06, Last modification date: 2023-12-13)

• Primary citation: Elkins, J.,Amos, A.,Niesen, F.,Pike, A.C.W.,Fedorov, O.,Knapp, S.; Structure of Dystrophia Myotonica Protein Kinase.; Protein Sci., 18:782-, 2009; PubMed: 19309729; DOI: 10.1002/PRO.82

Experimental method

X-RAY DIFFRACTION (2.8 Å)