2V9J

Crystal structure of the regulatory fragment of mammalian AMPK in complexes with Mg.ATP-AMP

Summary for 2V9J

Related2V92 2V8Q 2F15
Descriptor5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ... (7 entities in total)
Functional Keywordsatp-binding, polymorphism, metal-binding, serine/threonine-protein kinase, kinase, magnesium, cbs domain, transferase, sterol biosynthesis, steroid biosynthesis, fatty acid biosynthesis, cholesterol biosynthesis, lipid synthesis, phosphorylation, nucleotide-binding
Biological sourceRATTUS NORVEGICUS (RAT)
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Total number of polymer chains3
Total molecular weight66520.9
Authors
Xiao, B.,Heath, R.,Saiu, P.,Leiper, F.C.,Leone, P.,Jing, C.,Walker, P.A.,Haire, L.,Eccleston, J.F.,Davis, C.T.,Martin, S.R.,Carling, D.,Gamblin, S.J. (deposition date: 2007-08-23, release date: 2007-09-25, Last modification date: 2011-07-13)
Primary citation
Xiao, B.,Heath, R.,Saiu, P.,Leiper, F.C.,Leone, P.,Jing, C.,Walker, P.A.,Haire, L.,Eccleston, J.F.,Davis, C.T.,Martin, S.R.,Carling, D.,Gamblin, S.J.
Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature, 449:496-, 2007
PubMed: 17851531 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE06161
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.53 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers103.0%10.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution