2V4Z

The crystal structure of the human G-protein subunit alpha (GNAI3) in complex with an engineered regulator of G-protein signaling type 2 domain (RGS2)

2V4Z の概要

• エントリーDOI: 10.2210/pdb2v4z/pdb
• 関連するPDBエントリー: 2AF0 2IHB
• 分子名称: GUANINE NUCLEOTIDE-BINDING PROTEIN G(K) SUBUNIT ALPHA, REGULATOR OF G-PROTEIN SIGNALING 2, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: gtp hydrolysis, adp-ribosylation, nucleotide-binding, lipoprotein, gtp-binding, phosphoprotein, signal transduction inhibitor, guanine nucleotide binding protein, transmembrane signaling, g-protein coupled receptor, palmitate, myristate, transducer, cell cycle
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Isoform 1: Cell membrane . Isoform 2: Cell membrane . Isoform 3: Cell membrane . Isoform 4: Cell membrane : P41220
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57193.59

構造登録者

Roos, A.K.,Soundararajan, M.,Pike, A.C.W.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Bountra, C.,Knapp, S. (登録日: 2008-09-30, 公開日: 2008-11-04, 最終更新日: 2023-12-13)

• 主引用文献: Kimple, A.J.,Soundararajan, M.,Hutsell, S.Q.,Roos, A.K.,Urban, D.J.,Setola, V.,Temple, B.R.,Roth, B.L.,Knapp, S.,Willard, F.S.,Siderovski, D.P.; Structural Determinants of G-Protein Alpha Subunit Selectivity by Regulator of G-Protein Signaling 2(Rgs2).; J.Biol.Chem., 284:19402-, 2009; PubMed: 19478087; DOI: 10.1074/JBC.M109.024711

実験手法

X-RAY DIFFRACTION (2.8 Å)