2V2E

Structure of isoniazid (INH) bound to cytochrome c peroxidase mutant N184R Y36A

2V2E の概要

• エントリーDOI: 10.2210/pdb2v2e/pdb
• 関連するPDBエントリー: 1A2F 1A2G 1AA4 1AC4 1AC8 1AEB 1AED 1AEE 1AEF 1AEG 1AEH 1AEJ 1AEK 1AEM 1AEN 1AEO 1AEQ 1AES 1AET 1AEU 1AEV 1BEJ 1BEK 1BEM 1BEP 1BEQ 1BES 1BJ9 1BVA 1CCA 1CCB 1CCC 1CCE 1CCG 1CCI 1CCJ 1CCK 1CCL 1CCP 1CMP 1CMQ 1CMT 1CMU 1CPD 1CPE 1CPF 1CPG 1CYF 1DCC 1DJ1 1DJ5 1DS4 1DSE 1DSG 1DSO 1DSP 1EBE 1JCI 1JDR 1KOK 1KRJ 1KXM 1KXN 1MK8 1MKQ 1MKR 1ML2 1RYC 1S6V 1SDQ 1SOG 1STQ 1U74 1U75 1Z53 1ZBY 1ZBZ 2B0Z 2B10 2B11 2B12 2BCN 2CCP 2CEP 2CYP 2GB8 2PCB 2PCC 2V23 3CCP 3CCX 4CCP 4CCX 5CCP 6CCP 7CCP
• 分子名称: CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, 4-(DIAZENYLCARBONYL)PYRIDINE, ... (4 entities in total)
• 機能のキーワード: cytochrome c peroxidase, transit peptide, organic radical, hydrogen peroxide, inh, ccp, iron, heme, isoniazid, peroxidase, mitochondrion, metal-binding, oxidoreductase
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34335.02

構造登録者

Metcalfe, C.L.,Macdonald, I.K.,Brown, K.A.,Raven, E.L.,Moody, P.C.E. (登録日: 2007-06-05, 公開日: 2007-12-04, 最終更新日: 2023-12-13)

• 主引用文献: Metcalfe, C.L.,Macdonald, I.K.,Murphy, E.J.,Brown, K.A.,Raven, E.L.,Moody, P.C.E.; The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases.; J.Biol.Chem., 283:6193-, 2008; PubMed: 18056997; DOI: 10.1074/JBC.M707412200

実験手法

X-RAY DIFFRACTION (1.68 Å)