2V12

Crystal Structure of Renin with Inhibitor 8

Summary for 2V12

Related1BBS 1BIL 1BIM 1HRN 1PR7 1PR8 1RNE 1UHQ 2BKS 2BKT 2G20 2REN 2V0Z 2V10 2V11 2V13 2V16
DescriptorRENIN, N-[(2S,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-7-METHYL-2-(1-METHYLETHYL)-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE (2 entities in total)
Functional Keywordsglycoprotein, inhibitor-complex, aspartyl protease, zymogen, protease, hydrolase, polymorphism, alternative splicing, hydrolase(acid proteinase), cleavage on pair of basic residues
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight75521.37
Authors
Rahuel, J.,Rasetti, V.,Maibaum, J.,Rueger, H.,Goschke, R.,Cohen, N.C.,Stutz, S.,Cumin, F.,Fuhrer, W.,Wood, J.M.,Grutter, M.G. (deposition date: 2007-05-21, release date: 2007-07-03, Last modification date: 2019-04-03)
Primary citation
Rahuel, J.,Rasetti, V.,Maibaum, J.,Rueger, H.,Goschke, R.,Cohen, N.C.,Stutz, S.,Cumin, F.,Fuhrer, W.,Wood, J.M.,Grutter, M.G.
Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7:493-, 2000
PubMed: 10903938 (PDB entries with the same primary citation)
DOI: 10.1016/S1074-5521(00)00134-4
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers17 3.5% 18.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 2v12
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Molmil generated image of 2v12
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Molmil generated image of 2v12
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2v12.pdb2.gz [91.68 KB])
Coordinate files for Biological unit (2v12.pdb1.gz [91.68 KB])