2V11

Crystal Structure of Renin with Inhibitor 6

2V11 の概要

関連するPDBエントリー1BBS 1BIL 1BIM 1HRN 1PR7 1PR8 1RNE 1UHQ 2BKS 2BKT 2G20 2REN 2V0Z 2V10 2V12 2V13 2V16
分子名称RENIN, (2S,4S,5R,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL 1-BENZYL-1H-INDOLE-3-CARBOXYLATE (2 entities in total)
機能のキーワードglycoprotein, inhibitor-complex, aspartyl protease, zymogen, protease, hydrolase, polymorphism, alternative splicing, hydrolase(acid proteinase), cleavage on pair of basic residues
由来する生物種HOMO SAPIENS (HUMAN)
ポリマー鎖数2
分子量合計75549.34
構造登録者
Rahuel, J.,Rasetti, V.,Maibaum, J.,Rueger, H.,Goschke, R.,Cohen, N.C.,Stutz, S.,Cumin, F.,Fuhrer, W.,Wood, J.M.,Grutter, M.G. (登録日: 2007-05-21, 公開日: 2007-07-03, 最終更新日: 2019-04-03)
主引用文献
Rahuel, J.,Rasetti, V.,Maibaum, J.,Rueger, H.,Goschke, R.,Cohen, N.C.,Stutz, S.,Cumin, F.,Fuhrer, W.,Wood, J.M.,Grutter, M.G.
Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7:493-, 2000
PubMed: 10903938 (主引用文献が同じPDBエントリー)
DOI: 10.1016/S1074-5521(00)00134-4
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.1 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers14 3.0% 15.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード