2V0G

LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A tRNA(leu) transcript with 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) forming an adduct to the ribose of adenosine- 76 in the enzyme editing site.

Summary for 2V0G

• Entry DOI: 10.2210/pdb2v0g/pdb
• Related: 1H3N 1OBC 1OBH 2BTE 2BYT 2V0C
• Descriptor: AMINOACYL-TRNA SYNTHETASE, TRNALEU, LEUCINE, ... (6 entities in total)
• Functional Keywords: class i aminoacyl- trna synthetase, protein biosynthesis, aminoacyl-trna synthetase, atp + l-leucine + trna (leu) gives amp + ppi l-leucyl-trna synthetase, metal-binding, nucleotide-binding zinc, ligase, editing, synthetase, atp-binding
• Biological source: THERMUS THERMOPHILUS; More
• Total number of polymer chains: 4
• Total formula weight: 258287.99

Authors

Rock, F.,Mao, W.,Yaremchuk, A.,Tukalo, M.,Crepin, T.,Zhou, H.,Zhang, Y.,Hernandez, V.,Akama, T.,Baker, S.,Plattner, J.,Shapiro, L.,Martinis, S.A.,Benkovic, S.J.,Cusack, S.,Alley, M.R.K. (deposition date: 2007-05-14, release date: 2007-07-03, Last modification date: 2023-12-13)

• Primary citation: Rock, F.,Mao, W.,Yaremchuk, A.,Tukalo, M.,Crepin, T.,Zhou, H.,Zhang, Y.,Hernandez, V.,Akama, T.,Baker, S.,Plattner, J.,Shapiro, L.,Martinis, S.A.,Benkovic, S.J.,Cusack, S.,Alley, M.R.K.; An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.; Science, 316:1759-, 2007; PubMed: 17588934; DOI: 10.1126/SCIENCE.1142189

Experimental method

X-RAY DIFFRACTION (3.5 Å)