2V01

Recombinant vertebrate calmodulin complexed with Pb

2V01 の概要

• エントリーDOI: 10.2210/pdb2v01/pdb
• 関連するPDBエントリー: 1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 2BE6 2F3Y 2F3Z 2V02
• 分子名称: CALMODULIN, LEAD (II) ION, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: methylation, phosphorylation, metal-binding protein, metal binding protein
• 由来する生物種: Homo sapiens (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18550.22

構造登録者

Kursula, P.,Majava, V. (登録日: 2007-05-04, 公開日: 2007-08-14, 最終更新日: 2023-12-13)

主引用文献

Kursula, P.,Majava, V.
A Structural Insight Into Lead Neurotoxicity and Calmodulin Activation by Heavy Metals.
Acta Crystallogr.,Sect.F, 63:653-, 2007

PubMed Abstract: Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans.

PubMed: 17671360
DOI: 10.1107/S1744309107034525

実験手法

X-RAY DIFFRACTION (2.15 Å)