2V02

Recombinant vertebrate calmodulin complexed with Ba

Summary for 2V02

Entry DOI	10.2210/pdb2v02/pdb
Related	1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 2BE6 2F3Y 2F3Z 2V01
Descriptor	CALMODULIN, CALCIUM ION, BARIUM ION, ... (4 entities in total)
Functional Keywords	calcium, acetylation, methylation, phosphorylation, ubl conjugation, metal-binding protein, metal binding protein
Biological source	Homo sapiens (HUMAN)
Total number of polymer chains	1
Total formula weight	17247.43
Authors	Kursula, P.,Majava, V. (deposition date: 2007-05-04, release date: 2007-08-14, Last modification date: 2023-12-13)
Primary citation	Kursula, P.,Majava, V. A Structural Insight Into Lead Neurotoxicity and Calmodulin Activation by Heavy Metals. Acta Crystallogr.,Sect.F, 63:653-, 2007 Cited by PubMed Abstract: Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans. PubMed: 17671360 DOI: 10.1107/S1744309107034525 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation