2V01
Recombinant vertebrate calmodulin complexed with Pb
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000086 | biological_process | G2/M transition of mitotic cell cycle |
A | 0000922 | cellular_component | spindle pole |
A | 0002027 | biological_process | regulation of heart rate |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005513 | biological_process | detection of calcium ion |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005813 | cellular_component | centrosome |
A | 0005819 | cellular_component | spindle |
A | 0005829 | cellular_component | cytosol |
A | 0005856 | cellular_component | cytoskeleton |
A | 0005876 | cellular_component | spindle microtubule |
A | 0005886 | cellular_component | plasma membrane |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0008076 | cellular_component | voltage-gated potassium channel complex |
A | 0010800 | biological_process | positive regulation of peptidyl-threonine phosphorylation |
A | 0010801 | biological_process | negative regulation of peptidyl-threonine phosphorylation |
A | 0010856 | molecular_function | adenylate cyclase activator activity |
A | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
A | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
A | 0016020 | cellular_component | membrane |
A | 0016240 | biological_process | autophagosome membrane docking |
A | 0019855 | molecular_function | calcium channel inhibitor activity |
A | 0019901 | molecular_function | protein kinase binding |
A | 0021762 | biological_process | substantia nigra development |
A | 0030017 | cellular_component | sarcomere |
A | 0031432 | molecular_function | titin binding |
A | 0031514 | cellular_component | motile cilium |
A | 0031954 | biological_process | positive regulation of protein autophosphorylation |
A | 0031982 | cellular_component | vesicle |
A | 0032465 | biological_process | regulation of cytokinesis |
A | 0032516 | biological_process | positive regulation of phosphoprotein phosphatase activity |
A | 0032991 | cellular_component | protein-containing complex |
A | 0034704 | cellular_component | calcium channel complex |
A | 0035307 | biological_process | positive regulation of protein dephosphorylation |
A | 0035458 | biological_process | cellular response to interferon-beta |
A | 0043209 | cellular_component | myelin sheath |
A | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
A | 0044325 | molecular_function | transmembrane transporter binding |
A | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
A | 0046872 | molecular_function | metal ion binding |
A | 0048306 | molecular_function | calcium-dependent protein binding |
A | 0050848 | biological_process | regulation of calcium-mediated signaling |
A | 0051343 | biological_process | positive regulation of cyclic-nucleotide phosphodiesterase activity |
A | 0051592 | biological_process | response to calcium ion |
A | 0055117 | biological_process | regulation of cardiac muscle contraction |
A | 0060314 | biological_process | regulation of ryanodine-sensitive calcium-release channel activity |
A | 0060315 | biological_process | negative regulation of ryanodine-sensitive calcium-release channel activity |
A | 0060316 | biological_process | positive regulation of ryanodine-sensitive calcium-release channel activity |
A | 0071346 | biological_process | cellular response to type II interferon |
A | 0071902 | biological_process | positive regulation of protein serine/threonine kinase activity |
A | 0072542 | molecular_function | protein phosphatase activator activity |
A | 0097225 | cellular_component | sperm midpiece |
A | 0098901 | biological_process | regulation of cardiac muscle cell action potential |
A | 0140056 | biological_process | organelle localization by membrane tethering |
A | 1901842 | biological_process | negative regulation of high voltage-gated calcium channel activity |
A | 1901844 | biological_process | regulation of cell communication by electrical coupling involved in cardiac conduction |
A | 1902494 | cellular_component | catalytic complex |
A | 1905913 | biological_process | negative regulation of calcium ion export across plasma membrane |
A | 1990456 | biological_process | mitochondrion-endoplasmic reticulum membrane tethering |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PB A1146 |
Chain | Residue |
A | ASP118 |
A | ASP122 |
A | HOH2048 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PB A1147 |
Chain | Residue |
A | ASP20 |
A | ASP22 |
A | ASP24 |
A | THR26 |
A | GLU31 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PB A1148 |
Chain | Residue |
A | ASP58 |
A | ASN60 |
A | THR62 |
A | GLU67 |
A | ASP56 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PB A1149 |
Chain | Residue |
A | ASP93 |
A | ASP95 |
A | ASN97 |
A | TYR99 |
A | GLU104 |
A | HOH2037 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PB A1150 |
Chain | Residue |
A | ASP129 |
A | ASP131 |
A | ASP133 |
A | GLN135 |
A | GLU140 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PB A1151 |
Chain | Residue |
A | ASN42 |
A | GLU47 |
A | ASP58 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PB A1152 |
Chain | Residue |
A | GLU14 |
A | ARG74 |
A | CA1154 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PB A1153 |
Chain | Residue |
A | ASN42 |
A | ASP58 |
A | ASP64 |
A | GLU67 |
A | HOH2028 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA A1154 |
Chain | Residue |
A | ARG74 |
A | ASP78 |
A | PB1152 |
A | HOH2030 |
Functional Information from PROSITE/UniProt
site_id | PS00018 |
Number of Residues | 13 |
Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL |
Chain | Residue | Details |
A | ASP20-LEU32 | |
A | ASP56-PHE68 | |
A | ASP93-LEU105 | |
A | ASP129-PHE141 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03 |
Chain | Residue | Details |
A | LYS21 | |
A | PHE68 | |
A | GLY23 | |
A | GLY25 | |
A | ILE27 | |
A | LEU32 | |
A | ALA57 | |
A | GLY59 | |
A | GLY61 | |
A | ILE63 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03 |
Chain | Residue | Details |
A | LYS94 | |
A | PHE141 | |
A | GLY96 | |
A | GLY98 | |
A | ILE100 | |
A | LEU105 | |
A | ILE130 | |
A | GLY132 | |
A | GLY134 | |
A | VAL136 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
Chain | Residue | Details |
A | ASP2 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | ASP22 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29 |
Chain | Residue | Details |
A | GLU45 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | GLU82 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | ASP95 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
A | ILE100 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | ALA102 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | ASN111 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315 |
Chain | Residue | Details |
A | LEU116 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
A | GLU139 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157 |
Chain | Residue | Details |
A | ASP22 |