2UZR
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K)
Summary for 2UZR
Entry DOI | 10.2210/pdb2uzr/pdb |
Related | 1H10 1UNP 1UNQ 1UNR 2UVM 2UZS |
Descriptor | RAC-alpha serine/threonine-protein kinase (2 entities in total) |
Functional Keywords | transferase, glycogen biosynthesis, translation regulation, nucleotide- binding, glycogen metabolism, atp-binding, sugar transport, nuclear protein, serine/threonine-protein kinase, transport, carbohydrate metabolism, kinase, apoptosis, phosphorylation, glucose metabolism |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14773.73 |
Authors | Carpten, J.D.,Faber, A.L.,Horn, C.,Donoho, G.P.,Briggs, S.L.,Robbins, C.M.,Hostetter, G.,Boguslawski, S.,Moses, T.Y.,Savage, S.,Uhlik, M.,Lin, A.,Du, J.,Qian, Y.W.,Zeckner, D.J.,Tucker-Kellogg, G.,Touchman, J.,Patel, K.,Mousses, S.,Bittner, M.,Schevitz, R.,Lai, M.H.,Blanchard, K.L.,Thomas, J.E. (deposition date: 2007-05-01, release date: 2007-07-17, Last modification date: 2023-12-13) |
Primary citation | Carpten, J.D.,Faber, A.L.,Horn, C.,Donoho, G.P.,Briggs, S.L.,Robbins, C.M.,Hostetter, G.,Boguslawski, S.,Moses, T.Y.,Savage, S.,Uhlik, M.,Lin, A.,Du, J.,Qian, Y.W.,Zeckner, D.J.,Tucker-Kellogg, G.,Touchman, J.,Patel, K.,Mousses, S.,Bittner, M.,Schevitz, R.,Lai, M.H.,Blanchard, K.L.,Thomas, J.E. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature, 448:439-444, 2007 Cited by PubMed: 17611497DOI: 10.1038/nature05933 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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