2UZK
Crystal structure of the human FOXO3a-DBD bound to DNA
Summary for 2UZK
Entry DOI | 10.2210/pdb2uzk/pdb |
Descriptor | FORKHEAD BOX PROTEIN O3A, 5'-D(*CP*TP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*AP*G)-3', ... (4 entities in total) |
Functional Keywords | transcription, transcription regulation, chromosomal rearrangement, activator, apoptosis, dna-binding, winged helix, proto-oncogene, forkhead transcription factors, nuclear protein, phosphorylation, dna-binding domain |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm, cytosol: O43524 |
Total number of polymer chains | 6 |
Total formula weight | 37919.43 |
Authors | Tsai, K.-L.,Sun, Y.-J.,Huang, C.-Y.,Yang, J.-Y.,Hung, M.-C.,Hsiao, C.-D. (deposition date: 2007-04-30, release date: 2008-05-13, Last modification date: 2023-12-13) |
Primary citation | Tsai, K.-L.,Sun, Y.-J.,Huang, C.-Y.,Yang, J.-Y.,Hung, M.-C.,Hsiao, C.-D. Crystal Structure of the Human Foxo3A-Dbd/DNA Complex Suggests the Effects of Post-Translational Modification. Nucleic Acids Res., 35:6984-, 2007 Cited by PubMed: 17940099DOI: 10.1093/NAR/GKM703 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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