2UYP

Crystal structure of E. coli TdcF with bound propionate

Summary for 2UYP

Entry DOI	10.2210/pdb2uyp/pdb
Related	2UYJ 2UYK 2UYN
Descriptor	PROTEIN TDCF, PROPANOIC ACID (3 entities in total)
Functional Keywords	yjgf/yer057c/uk114 family, 2-ketobutyrate, unknown function, propionate, tdcf protein, ligand binding
Biological source	ESCHERICHIA COLI
Total number of polymer chains	3
Total formula weight	42352.47
Authors	Burman, J.D.,Stevenson, C.E.M.,Sawers, R.G.,Lawson, D.M. (deposition date: 2007-04-11, release date: 2007-05-29, Last modification date: 2023-12-13)
Primary citation	Burman, J.D.,Stevenson, C.E.M.,Sawers, R.G.,Lawson, D.M. The Crystal Structure of Escherichia Coli Tdcf, a Member of the Highly Conserved Yjgf/Yer057C/Uk114 Family. Bmc Struct.Biol., 7:30-, 2007 Cited by PubMed Abstract: The YjgF/YER057c/UK114 family of proteins is widespread in nature, but has as yet no clearly defined biological role. Members of the family exist as homotrimers and are characterised by intersubunit clefts that are delineated by well-conserved residues; these sites are likely to be of functional significance, yet catalytic activity has never been detected for any member of this family. The gene encoding the TdcF protein of E. coli, a YjgF/YER057c/UK114 family member, resides in an operon that strongly suggests a role in the metabolism of 2-ketobutyrate for this protein. PubMed: 17506874 DOI: 10.1186/1472-6807-7-30 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation