2RK2

DHFR R-67 complexed with NADP

Summary for 2RK2

Entry DOI	10.2210/pdb2rk2/pdb
Related	2P4T 2RH2
Descriptor	Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (4 entities in total)
Functional Keywords	oxidoreductase, nadp, asymmetric ligand binding, antibiotic resistance, methotrexate resistance, one-carbon metabolism, trimethoprim resistance
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	7830.45
Authors	Krahn, J.M.,London, R.E. (deposition date: 2007-10-16, release date: 2008-06-03, Last modification date: 2023-08-30)
Primary citation	Krahn, J.M.,Jackson, M.R.,DeRose, E.F.,Howell, E.E.,London, R.E. Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry, 46:14878-14888, 2007 Cited by PubMed: 18052202 DOI: 10.1021/bi701532r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation