2RH4
Actinorhodin ketoreductase, actKR, with NADPH and Inhibitor Emodin
Summary for 2RH4
| Entry DOI | 10.2210/pdb2rh4/pdb |
| Related | 1X7G 1X7H 2RHC 2RHR |
| Descriptor | Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, ... (4 entities in total) |
| Functional Keywords | oxidoreductase, polyketide, actinorhodin, ketoreductase, combinatorial biosynthesis, short chain dehydrogenase/reductase |
| Biological source | Streptomyces coelicolor |
| Total number of polymer chains | 2 |
| Total formula weight | 59965.01 |
| Authors | Korman, T.P.,Tsai, S.-C. (deposition date: 2007-10-05, release date: 2008-08-19, Last modification date: 2023-08-30) |
| Primary citation | Korman, T.P.,Tan, Y.H.,Wong, J.,Luo, R.,Tsai, S.-C. Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase Biochemistry, 47:1837-1847, 2008 Cited by PubMed: 18205400DOI: 10.1021/bi7016427 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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