2RER

Crystal structure of the aromatase/cyclase domain of TcmN from Streptomyces glaucescens

Summary for 2RER

Entry DOI	10.2210/pdb2rer/pdb
Related	2RES 2REZ
Descriptor	Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN (2 entities in total)
Functional Keywords	cyclase, aromatase, polyketide, helix-grip, dehydratase, anticancer, antibiotic, antibiotic biosynthesis, methyltransferase, multifunctional enzyme, transferase, biosynthetic protein
Biological source	Streptomyces glaucescens
Total number of polymer chains	1
Total formula weight	19938.34
Authors	Ames, B.D.,Korman, T.P.,Vu, T.N.,Tsai, S.C. (deposition date: 2007-09-26, release date: 2008-04-22, Last modification date: 2024-02-21)
Primary citation	Ames, B.D.,Korman, T.P.,Zhang, W.,Smith, P.,Vu, T.,Tang, Y.,Tsai, S.C. Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc.Natl.Acad.Sci.Usa, 105:5349-5354, 2008 Cited by PubMed: 18388203 DOI: 10.1073/pnas.0709223105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation