2RES
Tetracenomycin ARO/CYC mutant R69A
Summary for 2RES
| Entry DOI | 10.2210/pdb2res/pdb |
| Related | 2RER 2RES |
| Descriptor | Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN (2 entities in total) |
| Functional Keywords | tetracenomycin, polyketide, aromatase, cyclase, dehydratase, helix-grip, antibiotic biosynthesis, methyltransferase, multifunctional enzyme, transferase, lyase, biosynthetic protein |
| Biological source | Streptomyces glaucescens |
| Total number of polymer chains | 1 |
| Total formula weight | 19852.23 |
| Authors | Ames, B.D.,Tsai, S.C. (deposition date: 2007-09-26, release date: 2008-04-22, Last modification date: 2024-02-21) |
| Primary citation | Ames, B.D.,Korman, T.P.,Zhang, W.,Smith, P.,Vu, T.,Tang, Y.,Tsai, S.C. Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc.Natl.Acad.Sci.Usa, 105:5349-5354, 2008 Cited by PubMed: 18388203DOI: 10.1073/pnas.0709223105 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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