2RA3
Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI)
Summary for 2RA3
Entry DOI | 10.2210/pdb2ra3/pdb |
Related | 2R9P |
Descriptor | Trypsin-1, Pancreatic trypsin inhibitor, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | human cationic trypsin, serine protease, bovine pancreatic trypsin inhibitor, bpti, calcium, digestion, disease mutation, hydrolase, metal-binding, secreted, sulfation, zymogen, pharmaceutical, protease inhibitor, serine protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P07477 Secreted: P00974 |
Total number of polymer chains | 4 |
Total formula weight | 63645.11 |
Authors | Salameh, M.A.,Soares, A.S.,Radisky, E.S. (deposition date: 2007-09-14, release date: 2007-12-11, Last modification date: 2023-08-30) |
Primary citation | Salameh, M.A.,Soares, A.S.,Hockla, A.,Radisky, E.S. Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin. J.Biol.Chem., 283:4115-4123, 2008 Cited by PubMed: 18077447DOI: 10.1074/jbc.M708268200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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