Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| A | 0072562 | cellular_component | blood microparticle |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0007586 | biological_process | digestion |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0022617 | biological_process | extracellular matrix disassembly |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0062023 | cellular_component | collagen-containing extracellular matrix |
| B | 0072562 | cellular_component | blood microparticle |
| C | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| I | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1 |
| Chain | Residue |
| A | GLU70 |
| A | ASN72 |
| A | VAL75 |
| A | GLU80 |
| A | HOH274 |
| A | HOH311 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 6 |
| Chain | Residue |
| A | HOH462 |
| A | HOH468 |
| C | LYS46 |
| A | LYS60 |
| A | SER61 |
| A | HOH398 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 10 |
| Chain | Residue |
| A | THR132 |
| A | SER164 |
| A | GLN165 |
| A | HOH351 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 12 |
| Chain | Residue |
| A | THR177 |
| A | SER178 |
| A | SO4247 |
| A | HOH465 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 14 |
| Chain | Residue |
| A | ARG90 |
| A | HOH346 |
| A | HOH383 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 247 |
| Chain | Residue |
| A | SO412 |
| A | ASN100 |
| A | SER178 |
| A | ASN179 |
| A | HOH338 |
| A | HOH465 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 248 |
| Chain | Residue |
| A | SER110 |
| A | ARG111 |
| A | HOH381 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 249 |
| Chain | Residue |
| A | LYS97 |
| A | LEU99 |
| A | TRP215 |
| A | HOH337 |
| C | ARG39 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1 |
| Chain | Residue |
| B | GLU70 |
| B | ASN72 |
| B | VAL75 |
| B | GLU77 |
| B | GLU80 |
| B | HOH291 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 4 |
| Chain | Residue |
| B | PHE184 |
| B | LEU185 |
| B | GLU186 |
| B | HOH268 |
| B | HOH329 |
| B | HOH334 |
| B | HOH400 |
| B | HOH427 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 5 |
| Chain | Residue |
| A | PRO173 |
| A | LYS175 |
| A | LYS224 |
| A | HOH367 |
| A | HOH394 |
| B | ASN115 |
| B | ALA116 |
| B | HOH384 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 7 |
| Chain | Residue |
| B | LYS60 |
| B | SER61 |
| B | HOH399 |
| B | HOH489 |
| B | HOH513 |
| B | HOH517 |
| I | LYS46 |
| I | LYS46 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 8 |
| Chain | Residue |
| B | LYS87 |
| B | HOH368 |
| B | HOH418 |
| I | ARG42 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 11 |
| Chain | Residue |
| B | ASN100 |
| B | PRO129 |
| B | ALA130 |
| B | THR132 |
| B | ASN179 |
| B | SO4248 |
| B | HOH383 |
| B | HOH387 |
| B | HOH389 |
| B | HOH485 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 15 |
| Chain | Residue |
| B | SER110 |
| B | ARG111 |
| B | HOH501 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 247 |
| Chain | Residue |
| B | ASN21 |
| B | GLN156 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 248 |
| Chain | Residue |
| B | SO411 |
| B | THR132 |
| B | GLN165 |
| B | THR177 |
| B | SER178 |
| B | HOH288 |
| B | HOH405 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 249 |
| Chain | Residue |
| B | LYS97 |
| B | LEU99 |
| B | LYS175 |
| B | TRP215 |
| I | ARG39 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 250 |
| Chain | Residue |
| B | ASN48 |
| B | LYS239 |
| B | ILE242 |
| B | HOH330 |
| B | HOH511 |
| B | ILE47 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 I 59 |
| Chain | Residue |
| I | GLU7 |
| I | ARG42 |
| I | HOH66 |
| I | HOH80 |
| I | HOH88 |
| I | HOH91 |
| I | HOH107 |
| site_id | CC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 I 60 |
| Chain | Residue |
| I | ARG20 |
| I | TYR35 |
| I | GLY37 |
| I | ALA40 |
| I | HOH72 |
| I | HOH79 |
| I | HOH104 |
| I | HOH120 |
| I | HOH128 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 I 61 |
| Chain | Residue |
| B | ASN84 |
| B | SER109 |
| B | SER110 |
| B | HOH490 |
| I | ARG1 |
| I | PRO2 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 I 62 |
| Chain | Residue |
| I | TYR10 |
| I | THR11 |
| I | GLY12 |
| site_id | CC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 I 63 |
| Chain | Residue |
| A | TYR151 |
| A | PRO152 |
| A | ASP153 |
| A | HOH251 |
| A | HOH291 |
| C | ARG17 |
| I | TYR23 |
| I | GLY28 |
| I | HOH100 |
| I | HOH121 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 59 |
| Chain | Residue |
| C | ARG20 |
| C | TYR35 |
| C | GLY37 |
| C | ALA40 |
| C | HOH73 |
| C | HOH77 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 60 |
| Chain | Residue |
| C | PHE4 |
| C | LYS41 |
| C | ARG42 |
| C | HOH84 |
| C | HOH109 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAGHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 | |
| site_id | PS00280 |
| Number of Residues | 19 |
| Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FvyGGCrakrnnFksaedC |
| Chain | Residue | Details |
| I | PHE33-CYS51 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Reactive bond for trypsin |
| Chain | Residue | Details |
| I | LYS15 | |
| C | LYS15 | |
| A | ALA195 | |
| B | HIS57 | |
| B | ASP102 | |
| B | ALA195 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU70 | |
| A | ASN72 | |
| A | VAL75 | |
| A | GLU80 | |
| B | GLU70 | |
| B | ASN72 | |
| B | VAL75 | |
| B | GLU80 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Required for specificity => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP189 | |
| B | ASP189 | |
| Chain | Residue | Details |
| A | TYR151 | |
| B | TYR151 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | ALA195 | |
| A | HIS57 | |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | ALA195 | |
| B | GLY193 | |
| B | HIS57 | |
| site_id | CSA11 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLN192 | |
| A | ASP102 | |
| A | ALA195 | |
| A | GLY193 | |
| A | CYS191 | |
| A | HIS57 | |
| A | ASP194 | |
| site_id | CSA12 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | GLN192 | |
| B | ASP102 | |
| B | ALA195 | |
| B | GLY193 | |
| B | CYS191 | |
| B | HIS57 | |
| B | ASP194 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | ALA195 | |
| B | HIS57 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | HIS57 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | HIS57 | |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ALA195 | |
| A | GLY193 | |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ALA195 | |
| B | GLY193 | |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ALA195 | |
| A | GLY196 | |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ALA195 | |
| B | GLY196 | |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | ALA195 | |
| A | GLY193 | |
| A | HIS57 | |
