2RA3
Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Trypsin-1 | polymer | 224 | 24102.2 | 2 | UniProt (P07477) Pfam (PF00089) | Homo sapiens (human) | Trypsin I, Cationic trypsinogen, Serine protease 1 |
| 2 | C, D (I, C) | Pancreatic trypsin inhibitor | polymer | 58 | 6527.6 | 2 | UniProt (P00974) Pfam (PF00014) | Bos taurus (cattle) | Basic protease inhibitor, BPI, BPTI, Aprotinin |
| 3 | E, M (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | AA, BA, CA, DA, F... (I, C, A, B) | SULFATE ION | non-polymer | 96.1 | 24 | Chemie (SO4) | |||
| 5 | EA, FA, GA, HA (A, B, I, C) | water | water | 18.0 | 643 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 246 (UniProt: P07477)
| PDB | External Database | Details |
|---|---|---|
| His 117 | Arg 122 | engineered mutation |
| Ala 195 | Ser 200 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61259.4 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 2385.7 | |
| All* | Total formula weight | 63645.1 |
