2R8J

Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA

Summary for 2R8J

• Entry DOI: 10.2210/pdb2r8j/pdb
• Related: 1JIH 2R8K
• Descriptor: DNA (5'-D(*DGP*DTP*DGP*DGP*DAP*DTP*DGP*DAP*DG)-3'), DNA (5'-D(P*DGP*DGP*DCP*DTP*DCP*DAP*DTP*DCP*DCP*DAP*DC)-3'), DNA polymerase eta, ... (7 entities in total)
• Functional Keywords: protein-cisplatin-dna-dntp complex, replication, transferase-dna complex, transferase/dna
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Nucleus: Q04049
• Total number of polymer chains: 6
• Total formula weight: 139190.34

Authors

Carell, T.,Alt, A.,Lammens, K. (deposition date: 2007-09-11, release date: 2007-12-11, Last modification date: 2023-08-30)

• Primary citation: Alt, A.,Lammens, K.,Chiocchini, C.,Lammens, A.,Pieck, J.C.,Kuch, D.,Hopfner, K.P.,Carell, T.; Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta; Science, 318:967-970, 2007; PubMed: 17991862; DOI: 10.1126/science.1148242

Experimental method

X-RAY DIFFRACTION (3.1 Å)