2R7Z

Cisplatin lesion containing RNA polymerase II elongation complex

Summary for 2R7Z

• Entry DOI: 10.2210/pdb2r7z/pdb
• Descriptor: 5'-D(*TP*AP*CP*TP*TP*GUP*CP*CP*CP*TP*CP*CP*TP*CP*AP*T)-3', DNA-directed RNA polymerase II subunit RPB7, DNA-directed RNA polymerases I, II, and III subunit RPABC3, ... (18 entities in total)
• Functional Keywords: transferase/dna/rna, dna damage, zinc-finger, dna-binding, phosphorylation, cisplatin lesion, misincorporation, rna polymerase ii, transcription- coupled repair, tcr, arrest, stalling, dna lesion, metal-binding, nuclear protein, transcription bubble, damage recognition, elongation complex, transferase, transcription, transferase-dna-rna complex, transcription-dna-rna hybrid complex, transcription/dna-rna hybrid
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Cellular location: Nucleus: P04050 P38902 P08518 P16370 P20433 P20434 P34087 P20436; Nucleus, nucleolus : P22139 P40422 P27999; Cytoplasm : P20435
• Total number of polymer chains: 15
• Total formula weight: 525499.57

Authors

Damsma, G.E.,Alt, A.,Brueckner, F.,Carell, T.,Cramer, P. (deposition date: 2007-09-10, release date: 2007-11-20, Last modification date: 2017-10-25)

• Primary citation: Damsma, G.E.,Alt, A.,Brueckner, F.,Carell, T.,Cramer, P.; Mechanism of transcriptional stalling at cisplatin-damaged DNA.; Nat.Struct.Mol.Biol., 14:1127-1133, 2007; PubMed: 17994106; DOI: 10.1038/nsmb1314

Experimental method

X-RAY DIFFRACTION (3.8 Å)