2R7Z

Cisplatin lesion containing RNA polymerase II elongation complex

2R7Z の概要

• エントリーDOI: 10.2210/pdb2r7z/pdb
• 分子名称: 5'-D(*TP*AP*CP*TP*TP*GUP*CP*CP*CP*TP*CP*CP*TP*CP*AP*T)-3', DNA-directed RNA polymerase II subunit RPB7, DNA-directed RNA polymerases I, II, and III subunit RPABC3, ... (18 entities in total)
• 機能のキーワード: transferase/dna/rna, dna damage, zinc-finger, dna-binding, phosphorylation, cisplatin lesion, misincorporation, rna polymerase ii, transcription- coupled repair, tcr, arrest, stalling, dna lesion, metal-binding, nuclear protein, transcription bubble, damage recognition, elongation complex, transferase, transcription, transferase-dna-rna complex, transcription-dna-rna hybrid complex, transcription/dna-rna hybrid
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Nucleus: P04050 P38902 P08518 P16370 P20433 P20434 P34087 P20436; Nucleus, nucleolus : P22139 P40422 P27999; Cytoplasm : P20435
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 525499.57

構造登録者

Damsma, G.E.,Alt, A.,Brueckner, F.,Carell, T.,Cramer, P. (登録日: 2007-09-10, 公開日: 2007-11-20, 最終更新日: 2017-10-25)

• 主引用文献: Damsma, G.E.,Alt, A.,Brueckner, F.,Carell, T.,Cramer, P.; Mechanism of transcriptional stalling at cisplatin-damaged DNA.; Nat.Struct.Mol.Biol., 14:1127-1133, 2007; PubMed: 17994106; DOI: 10.1038/nsmb1314

実験手法

X-RAY DIFFRACTION (3.8 Å)