2R6W

Estrogen receptor alpha ligand-binding domain complexed to a SERM

Summary for 2R6W

• Entry DOI: 10.2210/pdb2r6w/pdb
• Related: 2R6Y
• Descriptor: Estrogen receptor, [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl]{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}methanone (3 entities in total)
• Functional Keywords: estrogen receptor, ligand-binding domain, alternative splicing, dna-binding, lipid-binding, metal-binding, nucleus, phosphorylation, polymorphism, steroid-binding, transcription, transcription regulation, zinc, zinc-finger
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
• Total number of polymer chains: 2
• Total formula weight: 57569.56

Authors

Wang, Y. (deposition date: 2007-09-06, release date: 2008-04-08, Last modification date: 2023-08-30)

• Primary citation: Dai, S.Y.,Chalmers, M.J.,Bruning, J.,Bramlett, K.S.,Osborne, H.E.,Montrose-Rafizadeh, C.,Barr, R.J.,Wang, Y.,Wang, M.,Burris, T.P.,Dodge, J.A.,Griffin, P.R.; Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.; Proc.Natl.Acad.Sci.Usa, 105:7171-7176, 2008; PubMed: 18474858; DOI: 10.1073/pnas.0710802105

Experimental method

X-RAY DIFFRACTION (2 Å)