2R6W
Estrogen receptor alpha ligand-binding domain complexed to a SERM
Summary for 2R6W
Entry DOI | 10.2210/pdb2r6w/pdb |
Related | 2R6Y |
Descriptor | Estrogen receptor, [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl]{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}methanone (3 entities in total) |
Functional Keywords | estrogen receptor, ligand-binding domain, alternative splicing, dna-binding, lipid-binding, metal-binding, nucleus, phosphorylation, polymorphism, steroid-binding, transcription, transcription regulation, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 |
Total number of polymer chains | 2 |
Total formula weight | 57569.56 |
Authors | Wang, Y. (deposition date: 2007-09-06, release date: 2008-04-08, Last modification date: 2023-08-30) |
Primary citation | Dai, S.Y.,Chalmers, M.J.,Bruning, J.,Bramlett, K.S.,Osborne, H.E.,Montrose-Rafizadeh, C.,Barr, R.J.,Wang, Y.,Wang, M.,Burris, T.P.,Dodge, J.A.,Griffin, P.R. Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Proc.Natl.Acad.Sci.Usa, 105:7171-7176, 2008 Cited by PubMed: 18474858DOI: 10.1073/pnas.0710802105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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