2R6W

Estrogen receptor alpha ligand-binding domain complexed to a SERM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Estrogen receptor	polymer	248	28297.2	2	UniProt (P03372) Pfam (PF00104)	Homo sapiens (human)	ER, Estradiol receptor, ER-alpha
2	C, D (A, B)	[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl]{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}methanone	non-polymer		487.6	2	Chemie (LLB)
3	E, F (A, B)	water	water		18.0	104	Chemie (HOH)

Sequence modifications

A, B: 304 - 551 (UniProt: P03372)

PDB	External Database	Details
Ser 381	Cys 381	engineered mutation
Ser 417	Cys 417	engineered mutation
Ser 530	Cys 530	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56594.3
Non-Polymers*	Number of molecules	2
	Total formula weight	975.2
All*	Total formula weight	57569.6

*Water molecules are not included.