2R3V
The Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism
Summary for 2R3V
Entry DOI | 10.2210/pdb2r3v/pdb |
Descriptor | Mevalonate kinase (2 entities in total) |
Functional Keywords | mevalonate kinase, farnesyl thiodiphophate, atp-binding, cataract, cholesterol biosynthesis, cytoplasm, disease mutation, lipid synthesis, nucleotide-binding, peroxisome, polymorphism, steroid biosynthesis, sterol biosynthesis, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q03426 |
Total number of polymer chains | 4 |
Total formula weight | 169991.05 |
Authors | Fu, Z.,Voynova, N.E.,Miziorko, H.M.,Kim, J.P. (deposition date: 2007-08-30, release date: 2008-06-24, Last modification date: 2023-08-30) |
Primary citation | Fu, Z.,Voynova, N.E.,Herdendorf, T.J.,Miziorko, H.M.,Kim, J.J. Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism. Biochemistry, 47:3715-3724, 2008 Cited by PubMed: 18302342DOI: 10.1021/bi7024386 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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