Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2R3V

The Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004496	molecular_function	mevalonate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006695	biological_process	cholesterol biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
A	0016126	biological_process	sterol biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
A	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
A	0033489	biological_process	cholesterol biosynthetic process via desmosterol
A	0033490	biological_process	cholesterol biosynthetic process via lathosterol
A	0036197	biological_process	zymosterol biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0050728	biological_process	negative regulation of inflammatory response
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004496	molecular_function	mevalonate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005777	cellular_component	peroxisome
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0006695	biological_process	cholesterol biosynthetic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008299	biological_process	isoprenoid biosynthetic process
B	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
B	0016126	biological_process	sterol biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
B	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
B	0033489	biological_process	cholesterol biosynthetic process via desmosterol
B	0033490	biological_process	cholesterol biosynthetic process via lathosterol
B	0036197	biological_process	zymosterol biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0050728	biological_process	negative regulation of inflammatory response
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004496	molecular_function	mevalonate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005777	cellular_component	peroxisome
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006694	biological_process	steroid biosynthetic process
C	0006695	biological_process	cholesterol biosynthetic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008299	biological_process	isoprenoid biosynthetic process
C	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
C	0016126	biological_process	sterol biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
C	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
C	0033489	biological_process	cholesterol biosynthetic process via desmosterol
C	0033490	biological_process	cholesterol biosynthetic process via lathosterol
C	0036197	biological_process	zymosterol biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0050728	biological_process	negative regulation of inflammatory response
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004496	molecular_function	mevalonate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005777	cellular_component	peroxisome
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006694	biological_process	steroid biosynthetic process
D	0006695	biological_process	cholesterol biosynthetic process
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0008299	biological_process	isoprenoid biosynthetic process
D	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
D	0016126	biological_process	sterol biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
D	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
D	0033489	biological_process	cholesterol biosynthetic process via desmosterol
D	0033490	biological_process	cholesterol biosynthetic process via lathosterol
D	0036197	biological_process	zymosterol biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0050728	biological_process	negative regulation of inflammatory response

Functional Information from PROSITE/UniProt

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. LPpGaGLGSSAA

Chain	Residue	Details
A	LEU137-ALA148

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11278915","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"9325256","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P17256","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
A	THR243

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
B	THR243

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
C	THR243

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
D	THR243

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)