2R3V

The Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004496	molecular_function	mevalonate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006695	biological_process	cholesterol biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016126	biological_process	sterol biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0050728	biological_process	negative regulation of inflammatory response
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004496	molecular_function	mevalonate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005777	cellular_component	peroxisome
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0006695	biological_process	cholesterol biosynthetic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016126	biological_process	sterol biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0050728	biological_process	negative regulation of inflammatory response
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004496	molecular_function	mevalonate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005777	cellular_component	peroxisome
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006694	biological_process	steroid biosynthetic process
C	0006695	biological_process	cholesterol biosynthetic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016126	biological_process	sterol biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0050728	biological_process	negative regulation of inflammatory response
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004496	molecular_function	mevalonate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005777	cellular_component	peroxisome
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006694	biological_process	steroid biosynthetic process
D	0006695	biological_process	cholesterol biosynthetic process
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016126	biological_process	sterol biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0050728	biological_process	negative regulation of inflammatory response

Functional Information from PROSITE/UniProt

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. LPpGaGLGSSAA

Chain	Residue	Details
A	LEU137-ALA148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:11278915

Chain	Residue	Details
A	SER146
B	SER146
C	SER146
D	SER146

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:9325256

Chain	Residue	Details
A	ASP204
B	ASP204
C	ASP204
D	ASP204

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site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P17256

Chain	Residue	Details
A	LYS13
B	GLY140
B	SER146
B	GLU193
C	LYS13
C	ASN55
C	SER135
C	GLY140
C	SER146
C	GLU193
D	LYS13
A	ASN55
D	ASN55
D	SER135
D	GLY140
D	SER146
D	GLU193
A	SER135
A	GLY140
A	SER146
A	GLU193
B	LYS13
B	ASN55
B	SER135

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
A	THR243

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
B	THR243

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site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
C	THR243

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site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
D	THR243

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