Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2R3V

The Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004496	molecular_function	mevalonate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006695	biological_process	cholesterol biosynthetic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
A	0042802	molecular_function	identical protein binding
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046872	molecular_function	metal ion binding
A	0050728	biological_process	negative regulation of inflammatory response
B	0000287	molecular_function	magnesium ion binding
B	0004496	molecular_function	mevalonate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005777	cellular_component	peroxisome
B	0005829	cellular_component	cytosol
B	0006695	biological_process	cholesterol biosynthetic process
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
B	0042802	molecular_function	identical protein binding
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046872	molecular_function	metal ion binding
B	0050728	biological_process	negative regulation of inflammatory response
C	0000287	molecular_function	magnesium ion binding
C	0004496	molecular_function	mevalonate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005777	cellular_component	peroxisome
C	0005829	cellular_component	cytosol
C	0006695	biological_process	cholesterol biosynthetic process
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
C	0042802	molecular_function	identical protein binding
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046872	molecular_function	metal ion binding
C	0050728	biological_process	negative regulation of inflammatory response
D	0000287	molecular_function	magnesium ion binding
D	0004496	molecular_function	mevalonate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005777	cellular_component	peroxisome
D	0005829	cellular_component	cytosol
D	0006695	biological_process	cholesterol biosynthetic process
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
D	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
D	0042802	molecular_function	identical protein binding
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0046872	molecular_function	metal ion binding
D	0050728	biological_process	negative regulation of inflammatory response

Functional Information from PROSITE/UniProt

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. LPpGaGLGSSAA

Chain	Residue	Details
A	LEU137-ALA148

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000305\|PubMed:11278915

Chain	Residue	Details
A	SER146
B	SER146
C	SER146
D	SER146

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:9325256

Chain	Residue	Details
A	ASP204
B	ASP204
C	ASP204
D	ASP204

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P17256

Chain	Residue	Details
A	LYS13
B	GLY140
B	SER146
B	GLU193
C	LYS13
C	ASN55
C	SER135
C	GLY140
C	SER146
C	GLU193
D	LYS13
A	ASN55
D	ASN55
D	SER135
D	GLY140
D	SER146
D	GLU193
A	SER135
A	GLY140
A	SER146
A	GLU193
B	LYS13
B	ASN55
B	SER135

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
A	THR243

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
B	THR243

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
C	THR243

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
D	THR243

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)