2R2W

Urokinase plasminogen activator B-chain-GPPE complex

Summary for 2R2W

Entry DOI	10.2210/pdb2r2w/pdb
Descriptor	Plasminogen activator, urokinase, SULFATE ION, 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine, ... (4 entities in total)
Functional Keywords	urokinase, inhibitor, serine protease, egf-like domain, hydrolase, kringle
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	28793.71
Authors	Zeslawska, E. (deposition date: 2007-08-28, release date: 2007-10-23, Last modification date: 2024-11-06)
Primary citation	Zeslawska, E.,Sturzebecher, J.,Oleksyn, B.J. Geometry of GPPE binding to picrate and to the urokinase type plasminogen activator. Bioorg.Med.Chem.Lett., 17:6212-6215, 2007 Cited by PubMed Abstract: Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two different environments was determined in order to compare the binding geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a target for anti-cancer drugs. It was shown that the conformation and the hydrogen-bonding formation by GPPE molecule are similar in both environments, but several important differences were discovered and described. PubMed: 17905583 DOI: 10.1016/j.bmcl.2007.09.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation