2R2U
Co(III)bleomycinB2 bithiazole/C-terminal tail domain bound to d(ATTTAGTTAACTAAAT) complexed with MMLV RT catalytic fragment
Summary for 2R2U
Entry DOI | 10.2210/pdb2r2u/pdb |
Related | 2R2R 2R2S 2R2T |
Descriptor | DNA (5'-D(*DAP*DTP*DTP*DTP*DAP*DGP*DT)-3'), DNA (5'-D(P*DTP*DAP*DCP*DTP*DAP*DAP*DAP*DT)-3'), Reverse transcriptase, ... (5 entities in total) |
Functional Keywords | bleomycin, drug-dna complex, protein-dna complex, mmlv rt, aspartyl protease, dna integration, dna recombination, endonuclease, hydrolase, multifunctional enzyme, nuclease, nucleotidyltransferase, protease, rna-directed dna polymerase, transferase, transferase-dna complex, transferase/dna |
Biological source | Moloney murine leukemia virus (MoMLV) |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor . Matrix protein p15: Virion . Capsid protein p30: Virion . Nucleocapsid protein p10: Virion : P03355 |
Total number of polymer chains | 3 |
Total formula weight | 33795.78 |
Authors | Goodwin, K.D.,Lewis, M.A.,Long, E.C.,Georgiadis, M.M. (deposition date: 2007-08-27, release date: 2008-07-22, Last modification date: 2023-08-30) |
Primary citation | Goodwin, K.D.,Lewis, M.A.,Long, E.C.,Georgiadis, M.M. Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding. Proc.Natl.Acad.Sci.Usa, 105:5052-5056, 2008 Cited by PubMed: 18362349DOI: 10.1073/pnas.0708143105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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