2R2M

2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors

2R2M の概要

• エントリーDOI: 10.2210/pdb2r2m/pdb
• 分子名称: Thrombin light chain, Thrombin heavy chain, Hirudin-3A, ... (5 entities in total)
• 機能のキーワード: thrombin, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, kringle, protease, secreted, serine protease, zymogen, protease inhibitor, serine protease inhibitor, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P28507
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 34711.00

構造登録者

Spurlino, J. (登録日: 2007-08-27, 公開日: 2008-08-26, 最終更新日: 2011-07-13)

• 主引用文献: Lee, L.,Kreutter, K.D.,Pan, W.,Crysler, C.,Spurlino, J.,Player, M.R.,Tomczuk, B.,Lu, T.; 2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors; Bioorg.Med.Chem.Lett., 17:6266-6269, 2007; PubMed: 17889527; DOI: 10.1016/j.bmcl.2007.09.013

実験手法

X-RAY DIFFRACTION (2.1 Å)