2R2L

Structure of Farnesyl Protein Transferase bound to PB-93

Summary for 2R2L

• Entry DOI: 10.2210/pdb2r2l/pdb
• Descriptor: Farnesyltransferase subunit alpha, Farnesyltransferase subunit beta, ZINC ION, ... (6 entities in total)
• Functional Keywords: malaria, fpt, transferase, metal-binding, phosphorylation, prenyltransferase, zinc
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 2
• Total formula weight: 83807.27

Authors

Strickland, C.O.,Voorhis, W. (deposition date: 2007-08-27, release date: 2008-03-11, Last modification date: 2024-02-21)

• Primary citation: Van Voorhis, W.C.,Rivas, K.L.,Bendale, P.,Nallan, L.,Horney, C.,Barrett, L.K.,Bauer, K.D.,Smart, B.P.,Ankala, S.,Hucke, O.,Verlinde, C.L.,Chakrabarti, D.,Strickland, C.,Yokoyama, K.,Buckner, F.S.,Hamilton, A.D.,Williams, D.K.,Lombardo, L.J.,Floyd, D.,Gelb, M.H.; Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.; Antimicrob.Agents Chemother., 51:3659-3671, 2007; PubMed: 17606674; DOI: 10.1128/AAC.00246-07

Experimental method

X-RAY DIFFRACTION (2.23 Å)