2QZO
Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with WAY-169916
Summary for 2QZO
Entry DOI | 10.2210/pdb2qzo/pdb |
Related | 2QXS |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol, ... (5 entities in total) |
Functional Keywords | protein-ligand complex, dna-binding, lipid-binding, metal-binding, nucleus, phosphorylation, receptor, steroid-binding, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 P03372 Nucleus : Q8BN74 |
Total number of polymer chains | 4 |
Total formula weight | 62829.89 |
Authors | Bruning, J.B.,Gil, G.,Nowak, J.,Katzenellenbogen, J.,Nettles, K.W. (deposition date: 2007-08-16, release date: 2008-08-26, Last modification date: 2024-10-09) |
Primary citation | Bruning, J.B.,Parent, A.A.,Gil, G.,Zhao, M.,Nowak, J.,Pace, M.C.,Smith, C.L.,Afonine, P.V.,Adams, P.D.,Katzenellenbogen, J.A.,Nettles, K.W. Coupling of receptor conformation and ligand orientation determine graded activity. Nat.Chem.Biol., 6:837-843, 2010 Cited by PubMed: 20924370DOI: 10.1038/nchembio.451 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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