2QXS
Crystal Structure of Antagonizing Mutant 536S of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to Raloxifene
Summary for 2QXS
| Entry DOI | 10.2210/pdb2qxs/pdb |
| Related | 2QZO |
| Descriptor | Estrogen receptor, RALOXIFENE (3 entities in total) |
| Functional Keywords | protein-ligand complex, dna-binding, lipid-binding, metal-binding, nucleus, phosphorylation, receptor, steroid-binding, transcription, transcription regulation, zinc-finger |
| Biological source | Homo sapiens (Human) |
| Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 |
| Total number of polymer chains | 2 |
| Total formula weight | 59972.65 |
| Authors | Bruning, J.B.,Gil, G.,Nowak, J.,Katzenellenbogen, J.,Nettles, K.W. (deposition date: 2007-08-12, release date: 2008-09-02, Last modification date: 2024-03-13) |
| Primary citation | Bruning, J.B.,Parent, A.A.,Gil, G.,Zhao, M.,Nowak, J.,Pace, M.C.,Smith, C.L.,Afonine, P.V.,Adams, P.D.,Katzenellenbogen, J.A.,Nettles, K.W. Coupling of receptor conformation and ligand orientation determine graded activity. Nat.Chem.Biol., 6:837-843, 2010 Cited by PubMed: 20924370DOI: 10.1038/nchembio.451 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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