2QXS

Crystal Structure of Antagonizing Mutant 536S of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to Raloxifene

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Estrogen receptor	polymer	258	29512.7	2	UniProt (P03372) Pfam (PF00104)	Homo sapiens (Human)	ER, Estradiol receptor, ER-alpha
2	C, D (A, B)	RALOXIFENE	non-polymer		473.6	2	Chemie (RAL)
3	E, F (A, B)	water	water		18.0	300	Chemie (HOH)

Sequence modifications

A, B: 298 - 554 (UniProt: P03372)

PDB	External Database	Details
Ser 297	-	expression tag
Ser 536	Leu 536	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	59025.5
Non-Polymers*	Number of molecules	2
	Total formula weight	947.2
All*	Total formula weight	59972.6

*Water molecules are not included.