2QZO
Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with WAY-169916
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 258 | 29462.7 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | B (B) | Estrogen receptor | polymer | 258 | 29538.8 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | |
| 3 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q8BN74) UniProt (by SIFTS) (Q61026) | Mus musculus | |
| 4 | E, F (A, B) | 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol | non-polymer | 334.3 | 2 | Chemie (KN1) | |||
| 5 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 422 | Chemie (HOH) |
Sequence modifications
A: 298 - 554 (UniProt: P03372)
B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 297 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 297 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62161.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 668.6 | |
| All* | Total formula weight | 62829.9 |
