2QYK
Crystal structure of PDE4A10 in complex with inhibitor NPV
Summary for 2QYK
Entry DOI | 10.2210/pdb2qyk/pdb |
Related | 2qyl 2qym 2qyn |
Descriptor | Cyclic AMP-specific phosphodiesterase HSPDE4A10, 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, ZINC ION, ... (5 entities in total) |
Functional Keywords | pde4 inhibitor, subfamily inhibitor selectivity, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 78170.04 |
Authors | Wang, H.,Peng, M.,Chen, Y.,Geng, J.,Robinson, H.,Houslay, M. (deposition date: 2007-08-15, release date: 2008-04-08, Last modification date: 2024-04-03) |
Primary citation | Wang, H.,Peng, M.S.,Chen, Y.,Geng, J.,Robinson, H.,Houslay, M.D.,Cai, J.,Ke, H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J., 408:193-201, 2007 Cited by PubMed: 17727341DOI: 10.1042/BJ20070970 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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