2QYK
Crystal structure of PDE4A10 in complex with inhibitor NPV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Cyclic AMP-specific phosphodiesterase HSPDE4A10 | polymer | 335 | 38624.0 | 2 | UniProt (Q9H3H2) Pfam (PF00233) UniProt (by SIFTS) (P27815) In PDB | Homo sapiens (human) | |
| 2 | A, B | 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid | non-polymer | 371.3 | 2 | Chemie (NPV) | |||
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 312 | Chemie (HOH) |
Sequence modifications
A, B: 290 - 622 (UniProt: Q9H3H2)
| PDB | External Database | Details |
|---|---|---|
| His 288 | - | expression tag |
| Met 289 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77247.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 922.1 | |
| All* | Total formula weight | 78170.0 |
