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2QXI

High resolution structure of Human Kallikrein 7 in Complex with Suc-Ala-Ala-Pro-Phe-chloromethylketone

Summary for 2QXI
Entry DOI10.2210/pdb2qxi/pdb
Related2QXG 2QXH 2QXJ
DescriptorKallikrein-7, N-(3-carboxypropanoyl)-L-alanyl-L-alanyl-N-[(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]-L-prolinamide (3 entities in total)
Functional Keywordss1 pocket, chloromethyl ketone, alternate conformations, alternative splicing, glycoprotein, hydrolase, protease, secreted, serine protease, zymogen
Biological sourceHomo sapiens (human)
Cellular locationSecreted : P49862
Total number of polymer chains1
Total formula weight25020.18
Authors
Debela, M.,Hess, P.,Magdolen, V.,Schechter, N.M.,Bode, W.,Goettig, P. (deposition date: 2007-08-11, release date: 2008-01-08, Last modification date: 2023-08-30)
Primary citationDebela, M.,Hess, P.,Magdolen, V.,Schechter, N.M.,Steiner, T.,Huber, R.,Bode, W.,Goettig, P.
Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7.
Proc.Natl.Acad.Sci.Usa, 104:16086-16091, 2007
Cited by
PubMed: 17909180
DOI: 10.1073/pnas.0707811104
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1 Å)
Structure validation

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