2QUX

PP7 coat protein dimer in complex with RNA hairpin

Summary for 2QUX

• Entry DOI: 10.2210/pdb2qux/pdb
• Related: 1DWN 2QUD
• Descriptor: RNA (25-MER), Coat protein, GLYCEROL, ... (4 entities in total)
• Functional Keywords: bacteriophage coat protein, rna-protein complex, capsid protein, structural protein-rna complex, structural protein/rna
• Biological source: Pseudomonas phage PP7; More
• Total number of polymer chains: 18
• Total formula weight: 213102.19

Authors

Chao, J.A. (deposition date: 2007-08-06, release date: 2007-12-18, Last modification date: 2023-08-30)

Primary citation

Chao, J.A.,Patskovsky, Y.,Almo, S.C.,Singer, R.H.
Structural basis for the coevolution of a viral RNA-protein complex.
Nat.Struct.Mol.Biol., 15:103-105, 2008

PubMed Abstract: The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved beta-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.

PubMed: 18066080
DOI: 10.1038/nsmb1327

Experimental method

X-RAY DIFFRACTION (2.44 Å)