2QNY

Crystal structure of the complex between the A246F mutant of mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and SS-(2-hydroxyethyl) O-decyl ester carbono(dithioperoxoic) acid

Summary for 2QNY

Entry DOI	10.2210/pdb2qny/pdb
Related	1HNJ 1HNK 1HZP 1U6E 1U6S 2QNX 2QNZ 2QO0 2QO1
Descriptor	3-oxoacyl-[acyl-carrier-protein] synthase 3, DECYL FORMATE, BETA-MERCAPTOETHANOL, ... (4 entities in total)
Functional Keywords	fatty acid biosynthesis, myobacterium tuberculosis, structural basis for substrate specificity, enzyme inhibitor complex, mechanism based inhibitor, acyltransferase, lipid synthesis, multifunctional enzyme, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	70565.95
Authors	Sachdeva, S.,Musayev, F.,Alhamadsheh, M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A. (deposition date: 2007-07-19, release date: 2008-05-06, Last modification date: 2023-08-30)
Primary citation	Sachdeva, S.,Musayev, F.N.,Alhamadsheh, M.M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A. Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH Chem.Biol., 15:402-412, 2008 Cited by PubMed: 18420147 DOI: 10.1016/j.chembiol.2008.03.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation