2QNY

Crystal structure of the complex between the A246F mutant of mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and SS-(2-hydroxyethyl) O-decyl ester carbono(dithioperoxoic) acid

2QNY の概要

• エントリーDOI: 10.2210/pdb2qny/pdb
• 関連するPDBエントリー: 1HNJ 1HNK 1HZP 1U6E 1U6S 2QNX 2QNZ 2QO0 2QO1
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 3, DECYL FORMATE, BETA-MERCAPTOETHANOL, ... (4 entities in total)
• 機能のキーワード: fatty acid biosynthesis, myobacterium tuberculosis, structural basis for substrate specificity, enzyme inhibitor complex, mechanism based inhibitor, acyltransferase, lipid synthesis, multifunctional enzyme, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70565.95

構造登録者

Sachdeva, S.,Musayev, F.,Alhamadsheh, M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A. (登録日: 2007-07-19, 公開日: 2008-05-06, 最終更新日: 2023-08-30)

• 主引用文献: Sachdeva, S.,Musayev, F.N.,Alhamadsheh, M.M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A.; Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH; Chem.Biol., 15:402-412, 2008; PubMed: 18420147; DOI: 10.1016/j.chembiol.2008.03.007

実験手法

X-RAY DIFFRACTION (2.15 Å)