2QL2

Crystal Structure of the basic-helix-loop-helix domains of the heterodimer E47/NeuroD1 bound to DNA

Summary for 2QL2

• Entry DOI: 10.2210/pdb2ql2/pdb
• Descriptor: Transcription factor E2-alpha, Neurogenic differentiation factor 1, DNA (5'-D(*DTP*DAP*DGP*DGP*DCP*DCP*DAP*DTP*DCP*DTP*DGP*DGP*DTP*DCP*DCP*DT)-3'), ... (5 entities in total)
• Functional Keywords: basic-helix-loop-helix, protein-dna complex, heterodimer, dna-binding, activator, developmental protein, differentiation, neurogenesis, nucleus, phosphorylation, transcription, transcription regulation, cytoplasm, phosphoprotein, transcription-dna complex, transcription/dna
• Biological source: Mus musculus (Mouse); More
• Cellular location: Cytoplasm (By similarity): 2QL2
• Total number of polymer chains: 8
• Total formula weight: 47849.93

Authors

Rose, R.B.,Longo, A.,Guanga, G.P. (deposition date: 2007-07-12, release date: 2008-11-04, Last modification date: 2023-08-30)

• Primary citation: Longo, A.,Guanga, G.P.,Rose, R.B.; Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition.; Biochemistry, 47:218-229, 2008; PubMed: 18069799; DOI: 10.1021/bi701527r

Experimental method

X-RAY DIFFRACTION (2.5 Å)