2QKY
complex structure of dipeptidyl peptidase IV and a oxadiazolyl ketone
Summary for 2QKY
Entry DOI | 10.2210/pdb2qky/pdb |
Descriptor | Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (Adenosine deaminase complexing protein 2) (ADABP) (Dipeptidyl peptidase 4 soluble form) (Dipeptidyl peptidase IV soluble form), 2-[(2-{(2S,4S)-2-[(R)-(5-tert-butyl-1,3,4-oxadiazol-2-yl)(hydroxy)methyl]-4-fluoropyrrolidin-1-yl}-2-oxoethyl)amino]-2-methylpropan-1-ol (3 entities in total) |
Functional Keywords | beta-propeller, dimer, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane |
Biological source | Homo sapiens (Human) |
Cellular location | Dipeptidyl peptidase 4 soluble form: Secreted . Cell membrane ; Single- pass type II membrane protein: P27487 |
Total number of polymer chains | 4 |
Total formula weight | 339396.33 |
Authors | Kim, K.-H.,Hong, S.Y.,Koo, K.D.,Lee, C.-S.,Kim, G.T.,Han, H.O. (deposition date: 2007-07-12, release date: 2008-07-15, Last modification date: 2023-08-30) |
Primary citation | Koo, K.D.,Kim, M.J.,Kim, S.,Kim, K.H.,Hong, S.Y.,Hur, G.C.,Yim, H.J.,Kim, G.T.,Han, H.O.,Kwon, O.H.,Kwon, T.S.,Koh, J.S.,Lee, C.S. Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones. Bioorg.Med.Chem.Lett., 17:4167-4172, 2007 Cited by PubMed: 17544668DOI: 10.1016/j.bmcl.2007.05.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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