2QKK
Human RNase H catalytic domain mutant D210N in complex with 14-mer RNA/DNA hybrid
Summary for 2QKK
Entry DOI | 10.2210/pdb2qkk/pdb |
Related | 2QK9 2QKB |
Descriptor | 5'-R(*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*G)-3', Ribonuclease H1, ... (8 entities in total) |
Functional Keywords | rnase h; rna/dna hybrid, hydrolase-dna-rna complex, hydrolase/dna/rna |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (Potential): O60930 |
Total number of polymer chains | 23 |
Total formula weight | 241521.99 |
Authors | Nowotny, M.,Gaidamakov, S.A.,Ghirlando, R.,Cerritelli, S.M.,Crouch, R.J.,Yang, W. (deposition date: 2007-07-11, release date: 2007-11-13, Last modification date: 2023-08-30) |
Primary citation | Nowotny, M.,Gaidamakov, S.A.,Ghirlando, R.,Cerritelli, S.M.,Crouch, R.J.,Yang, W. Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription Mol.Cell, 28:264-276, 2007 Cited by PubMed: 17964265DOI: 10.1016/j.molcel.2007.08.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
Download full validation report